ROSACEA DEVELOPMENT | TRIGGER CONTROL | REDNESS CONTROL
THREAD VEINS & TISSUE CHANGES | UK EVALUATION
THREAD VEINS & TISSUE CHANGES | UK EVALUATION
ROSACEA DEVELOPMENT
Rosacea subtype 1 is the most common form of rosacea characterised by reddening skin and thread veins with other subtypes usually but not always developing progressively. (See rosacea subtypes). Below is a schematic of the change skin tissue following triggering which cause the inflammatory response, the damage to capillary structure, the increase in vascular permeability and the results in the visible symptoms.
Underlying chemical processes triggered by UV for example are behind these processes whereby various chemicals are released creating a cascade process resulting in reddening and swelling. We show UV as the trigger here as it is probably for most the biggest contributor to the development of symptoms, but other triggers may well also contribute to initiating the process.
The schematics contain a number of abbreviations. ROS = reactive oxygen species or free radicals, but free radicals are only a part of the process leading to damage and loss of control of the reddening process. Release and/or inhibition of chemicals triggering irregular tissue growth may underpin phymatous changes (see subtypes) and vascular changes in blood vessel stability, while the early or excessive release of cellular chemicals coupled with the reduction in the release or activity of other cellular chemicals can lead to a cascade process resulting in more rapid and prolonged erythema (reddening and swelling). Examples of such chemicals which are involved in the process are PGE2 (Prostaglandins) and IL1(Interleukin) and Cytokines.
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So in fact triggers, whether they be hormonal, environmental, dietary or a combination of all, cause dilation of blood vessels, which in susceptible types (genetic type or through excessive acute exposure or exposure over time or a combination of all three) causes chemical changes in the skin resulting in a chemical cascade leading to erythema and in some, cellular and vascular irregularities which can become chronic and severe.
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In our view Demodex mites whether folliculorum or brevis may be another physical/chemical trigger factor, and are found in higher levels in rosacea skins because the their skin environment is more conducive for them. But we still believe the main trigger for most is UV exposure.
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Avoiding triggers from an early stage is an important part of preventing and managing rosacea, but although we cannot change our genetics or hormonal status easily and safely we can address a number of the reddening process listed above.
Synchrorose® has been shown to actively target some of these free radical, enzyme and chemical mediated cascades that are triggered, thereby offering a level of control whatever the underlying trigger factors. One has to achieve sustained levels of the active ingredients in the skin at a level whereby they influence the above processes.
Synchrorose® has been shown to:
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Photo-protection so on keratinocytes as on fibroblasts;
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Down-regulation of vascular endothelial growth factor - VEGF;
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Down regulation in the expression of PGE2;
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Inhibition of the release of IL-1 and TNF;
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Diminish the expression of CD80 and CD86 on monocytes;
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Inhibition of UV-B induced H202 production;
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Scavenging of ROS including hydroxyl radicals;
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Reduction of the UVB-induced infiltrating leukocytes;
Synchrorose® is far more than an antioxidant. The main outcomes of influencing the above processes are listed below:
